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Meal size and timing: Eating smaller, more frequent meals rather than two or three large meals reduces the GI discomfort that GLP-1 agonists can cause

This innovative smart hydrogel is an ideal candidate for clinical application and translational research [191]

This observation was demonstrated by vagotomy experiments [99] and pharmacological experiments using an icv injection of cholinergic tone inhibitors [100] in rodents receiving an exendin-4 brain infusion into the lateral ventricle

All such findings derive from laboratory, animal, and clinical-research settings and are reported here strictly as experimental observations